No, That will not be supported.
If you use MC in a single panel setup you are using it wrong, And you may accidentally do something on files that are in the "hidden" panel. because it still exists.
MC is designed to be used in a dual panel setup. Where the focus panel is the default target location and the opposite panel is the default target location.
MC is not designed to be used in single panel mode. Running with only a single panel a lot of features will unusable, and minimizing one panel to zero size only hides it. It is still there and can be used without you seeing what you are doing and that can be very dangerous..
